Hydroxylated Analogues of ATP-Sensitive Potassium Channel Openers Belonging to the Group of 6-and/or 7-Substituted 3-Isopropylamino-4 H-1, 2, 4- …

…, F Gillotin, F Somers, P Chiap, P Lebrun…

Index: De Tullio, Pascal; Servais, Anne-Catherine; Fillet, Marianne; Gillotin, Florian; Somers, Fabian; Chiap, Patrice; Lebrun, Philippe; Pirotte, Bernard Journal of Medicinal Chemistry, 2011 , vol. 54, # 24 p. 8353 - 8361

Full Text: HTML

Citation Number: 10

Abstract

Diversely substituted 3-isopropylamino-4 H-1, 2, 4-benzothiadiazine 1, 1-dioxides are known to be potent KATP channel openers, with several drugs being selective for the SUR1/Kir6. 2 channel subtype. This work examined the biological activity, tissue selectivity, and in vitro metabolic stability of hydroxylated analogues of 3- isopropylaminobenzothiadiazine dioxides. Because of the presence of a chiral center, the ...