e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

… A deficient hamster tracheal organ cultures. Single-crystal X-ray diffraction analysis of 4, 4-dimethylthiochroman-6-yl methyl ketone 1, 1-dioxide and ethyl (E)-p-[2-(4, 4 …

KM Waugh, KD Berlin, WT Ford, EM Holt…

Index: Waugh, Kristy M.; Berlin, K. Darrell; Ford, Warren T.; Holt, Elizabeth M.; Carrol, John P.; et al. Journal of Medicinal Chemistry, 1985 , vol. 28, # 1 p. 116 - 124

Full Text: HTML

Citation Number: 51

Abstract

There is reported the first four members of heteroarotinoids, the names of which are ethyl (E)- p-[2-(4, 4-dimethylthiochroman-6-yl) propenyl] benzoate (lb), ethyl (E)-p-[2-(4, 4- dimethylchroman-6-yl) propenyl] benzoate (IC), ethyl (E)-p-[2-(4, 4-dimethyl-l- oxothiochroman-6-yl) propenyl] benzoate (la), and (E)-p-[2-(4, 4-dimethylchroman-6-yl) propenyllbenzoic acid (le). IR,'Hnmr and 13C NMR data have been recorded for each ...

3-Phenoxypropionic acid Structure

3-Phenoxypropio...

~%

1-(4,4-dimethyl-2,3-dihydrochromen-6-yl)ethanone Structure

1-(4,4-dimethyl...

Propanoic acid,3-phenoxy-, methyl ester Structure

Propanoic acid,...

~%

1-(4,4-dimethyl-2,3-dihydrochromen-6-yl)ethanone Structure

1-(4,4-dimethyl...

2-methyl-4-phenoxybutan-2-ol Structure

2-methyl-4-phen...

~%

1-(4,4-dimethyl-2,3-dihydrochromen-6-yl)ethanone Structure

1-(4,4-dimethyl...

Benzene,[(3-methyl-2-buten-1-yl)thio]- Structure

Benzene,[(3-met...

~77%

4,4-DIMETHYL-THIOCHROMAN Structure

4,4-DIMETHYL-TH...

2-Methyl-4-(phenylthio)-2-butanol Structure

2-Methyl-4-(phe...

~79%

4,4-DIMETHYL-THIOCHROMAN Structure

4,4-DIMETHYL-TH...

3,3-Dimethylallyl bromide Structure

3,3-Dimethylall...

~%

4,4-DIMETHYL-THIOCHROMAN Structure

4,4-DIMETHYL-TH...

2H-1-Benzopyran,3,4-dihydro-4,4-dimethyl- Structure

2H-1-Benzopyran...

~%

ethyl 4-(2-(3,4-dihydro-4,4-dimethyl-2H-1 benzopyran-6-yl)-1-propenyl)benzoate Structure

ethyl 4-(2-(3,4...

3-Phenoxypropionic acid Structure

3-Phenoxypropio...

~%

ethyl 4-(2-(3,4-dihydro-4,4-dimethyl-2H-1 benzopyran-6-yl)-1-propenyl)benzoate Structure

ethyl 4-(2-(3,4...

Propanoic acid,3-phenoxy-, methyl ester Structure

Propanoic acid,...

~%

ethyl 4-(2-(3,4-dihydro-4,4-dimethyl-2H-1 benzopyran-6-yl)-1-propenyl)benzoate Structure

ethyl 4-(2-(3,4...

1-(4,4-dimethyl-2,3-dihydrochromen-6-yl)ethanone Structure

1-(4,4-dimethyl...

~%

ethyl 4-(2-(3,4-dihydro-4,4-dimethyl-2H-1 benzopyran-6-yl)-1-propenyl)benzoate Structure

ethyl 4-(2-(3,4...

N/A Structure

~%

ethyl 4-(2-(3,4-dihydro-4,4-dimethyl-2H-1 benzopyran-6-yl)-1-propenyl)benzoate Structure

ethyl 4-(2-(3,4...

2-methyl-4-phenoxybutan-2-ol Structure

2-methyl-4-phen...

~%

ethyl 4-(2-(3,4-dihydro-4,4-dimethyl-2H-1 benzopyran-6-yl)-1-propenyl)benzoate Structure

ethyl 4-(2-(3,4...

3-Phenoxypropionic acid Structure

3-Phenoxypropio...

~%

2H-1-Benzopyran,3,4-dihydro-4,4-dimethyl- Structure

2H-1-Benzopyran...

Propanoic acid,3-phenoxy-, methyl ester Structure

Propanoic acid,...

~%

2H-1-Benzopyran,3,4-dihydro-4,4-dimethyl- Structure

2H-1-Benzopyran...

Propanoic acid,3-phenoxy-, methyl ester Structure

Propanoic acid,...

Methylmagnesium chloride Structure

Methylmagnesium...

~77%

2-methyl-4-phenoxybutan-2-ol Structure

2-methyl-4-phen...

3-Phenoxypropionic acid Structure

3-Phenoxypropio...

~%

2-methyl-4-phenoxybutan-2-ol Structure

2-methyl-4-phen...

Benzoic acid,4-formyl-, ethyl ester Structure

Benzoic acid,4-...

[1-(4,4-dimethyl-6-chromanyl)ethyl]triphenylphosphonium bromide Structure

[1-(4,4-dimethy...

~%

N/A Structure

ethyl 4-(2-(3,4-dihydro-4,4-dimethyl-2H-1 benzopyran-6-yl)-1-propenyl)benzoate Structure

ethyl 4-(2-(3,4...

Benzoic acid,4-formyl-, ethyl ester Structure

Benzoic acid,4-...

N/A Structure

~%

ethyl 4-[(Z)-2-(4,4-dimethyl-2,3-dihydrothiochromen-6-yl)prop-1-enyl]benzoate Structure

ethyl 4-[(Z)-2-...

4,4-DIMETHYL-THIOCHROMAN Structure

4,4-DIMETHYL-TH...

~%

ethyl 4-[(Z)-2-(4,4-dimethyl-2,3-dihydrothiochromen-6-yl)prop-1-enyl]benzoate Structure

ethyl 4-[(Z)-2-...

Benzene,[(3-methyl-2-buten-1-yl)thio]- Structure

Benzene,[(3-met...

~%

ethyl 4-[(Z)-2-(4,4-dimethyl-2,3-dihydrothiochromen-6-yl)prop-1-enyl]benzoate Structure

ethyl 4-[(Z)-2-...

2-Methyl-4-(phenylthio)-2-butanol Structure

2-Methyl-4-(phe...

~%

ethyl 4-[(Z)-2-(4,4-dimethyl-2,3-dihydrothiochromen-6-yl)prop-1-enyl]benzoate Structure

ethyl 4-[(Z)-2-...

6-Acetyl-4,4-dimethylthio-chroman Structure

6-Acetyl-4,4-di...

~%

ethyl 4-[(Z)-2-(4,4-dimethyl-2,3-dihydrothiochromen-6-yl)prop-1-enyl]benzoate Structure

ethyl 4-[(Z)-2-...

α,4,4-trimethylthiochroman-6-methanol Structure

α,4,4-trimethyl...

~%

ethyl 4-[(Z)-2-(4,4-dimethyl-2,3-dihydrothiochromen-6-yl)prop-1-enyl]benzoate Structure

ethyl 4-[(Z)-2-...

3,3-Dimethylallyl bromide Structure

3,3-Dimethylall...

~%

ethyl 4-[(Z)-2-(4,4-dimethyl-2,3-dihydrothiochromen-6-yl)prop-1-enyl]benzoate Structure

ethyl 4-[(Z)-2-...

Ethyl 4-methylbenzoate Structure

Ethyl 4-methylb...

Ethanoic anhydride Structure

Ethanoic anhydride

~%

ethyl 4-(diacetyloxymethyl)benzoate Structure

ethyl 4-(diacet...

Ethyl 3-(phenylthio)propanoate Structure

Ethyl 3-(phenyl...

Methylmagnesium chloride Structure

Methylmagnesium...

~81%

2-Methyl-4-(phenylthio)-2-butanol Structure

2-Methyl-4-(phe...

Conformationally restricted retinoids

[Dawson, Marcia I.; Hobbs, Peter D.; Derdzinski, Krzysztof; Chan, Rebecca L.-S.; Gruber, John; et al. Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1516 - 1531]

Conformationally restricted retinoids

[Dawson, Marcia I.; Hobbs, Peter D.; Derdzinski, Krzysztof; Chan, Rebecca L.-S.; Gruber, John; et al. Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1516 - 1531]

Conformationally restricted retinoids

[Dawson, Marcia I.; Hobbs, Peter D.; Derdzinski, Krzysztof; Chan, Rebecca L.-S.; Gruber, John; et al. Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1516 - 1531]

Conformationally restricted retinoids

[Dawson, Marcia I.; Hobbs, Peter D.; Derdzinski, Krzysztof; Chan, Rebecca L.-S.; Gruber, John; et al. Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1516 - 1531]

Conformationally restricted retinoids

[Dawson, Marcia I.; Hobbs, Peter D.; Derdzinski, Krzysztof; Chan, Rebecca L.-S.; Gruber, John; et al. Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1516 - 1531]