3-Acyl-4-hydroxyquinolin-2 (1H)-ones. Systemically active anticonvulsants acting by antagonism at the glycine site of the N-methyl-D-aspartate receptor complex

…, GI Stevenson, AM Moseley, I Stansfield…

Index: Rowley, Michael; Leeson, Paul D.; Stevenson, Graeme I.; Moseley, Angela M.; Stansfield, Ian; et al. Journal of Medicinal Chemistry, 1993 , vol. 36, # 22 p. 3386 - 3396

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Citation Number: 97

Abstract

Synthesis Compound 414 is known. Oxindole 1 was prepared by hydrogenation of the nitroarylmalonate 5416 (Scheme I). The starting material for most of the compounds in this paper is a substituted anthranilic ester. Many anthranilic acids are commercially available and can be esterified by refluxing with an excess of concentrated sulfuric acid in ethanol for several days, or by treatment with ethereal diazomethane. Where the anthranilic acid is ...