Synthetic Communications

The synthesis of 13C9-15N-labeled 3, 5-diiodothyronine and thyroxine

SA Hackenmueller, TS Scanlan

Index: Hackenmueller, Sarah A.; Scanlan, Thomas S. Synthetic Communications, 2013 , vol. 43, # 10 p. 1439 - 1446

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Abstract

Thyroid hormones undergo extensive metabolism to regulate hormone activity. A labeled thyroid hormone would be useful to track hormone metabolism through various pathways. While radiolabeled thyroid hormones have been synthesized and used for in vivo studies, a stable isotope labeled form of thyroid hormone is required for studying thyroid hormone metabolism by LC-MS/MS, an analytical technique that has certain advantages without the complications of ...