Synthesis and evaluation of radioiodinated (E)-18-iodo-17-octadecenoic acid as a model iodoalkenyl fatty acid for myocardial imaging

…, MM Goodman, GW Kabalka, KAR Sastry

Index: Knapp, F. F.; Goodman, M. M.; Kabalka, G. W.; Sastry, K. A. R. Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 94 - 97

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Citation Number: 16

Abstract

Nuclear Medicine Group, Health and Safety Research Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830, and Chemistry Department, University of Tennessee, Knoxville, Tennessee 37916. Received June 20, 1983 l% I-labeled (E)-18-iodo- 17-octadecenoic acid (13) has been prepared and evaluated in rats to determine the myocardial uptake and retention and degree of in vivo deiodination of this model iodivinyl- ...