Fluorescent probes for dopamine receptors: synthesis and characterization of fluorescein and 7-nitrobenz-2-oxa-1, 3-diazol-4-yl conjugates of D-1 and D-2 receptor …

V Bakthavachalam, N Baindur, BK Madras…

Index: Bakthavachalam, Venkatesalu; Baindur, Nandkishore; Madras, Bertha K.; Neumeyer, John L. Journal of Medicinal Chemistry, 1991 , vol. 34, # 11 p. 3235 - 3241

Full Text: HTML

Citation Number: 23

Abstract

Fluorescent probes have been designed and developed for dopamine D-1 and D-2 receptors. Flourescein and/or NBD (7-nitrobenz-2-oxa-l, 3-diazol-4-y1) derivatives of PPHT (D-2 agonist), spiperone (D-2 antagonist), SKF 38393 (D-1 agonist), and SKF 83566 (D-1 antagonist) were synthesized via their amino-functionalized analogues and all ligands were pharmacologically evaluated by measuring their ability to displace [SH] SCH 23390 and [ ...