e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Relationship between chemical structure and anticonvulsive activity in 4, 4′-(α, ω-alkylenedioxy) diphenylsuccinimides

NS Nesunts, SA Avetisyan, IA Dzhagatspanyan…

Index: Nesunts, N. S.; Avetisyan, S. A.; Dzhagatspanyan, I. A.; Akopyan, N. E.; Mndzhoyan, O. L. Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 7 p. 480 - 484 Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 7 p. 801 - 806

Full Text: HTML

Citation Number: 5

Abstract

The relationship between chemical structure an4 anticonvulsant activity has recently been studied [i, 2] in some new succinimide derivatives. Since the structure of the receptors [3] which interact with anticonvulsant drugs, in particular pufemid, is as yet unkr~ own, it was of interest from a chemical-biological point of view to determine the distances between the active centers in these receptors by simultaneously blocking them with a single molecule ...

4,4'-(1,4-Butanediyl)dioxydibenzaldehyde Structure

4,4'-(1,4-Butan...

~%

3-[4-[4-[4-(2,5-dioxopyrrolidin-3-yl)phenoxy]butoxy]phenyl]pyrrolidine-2,5-dione Structure

3-[4-[4-[4-(2,5...

4-hydroxybenzaldehyde Structure

4-hydroxybenzal...

~%

3-[4-[4-[4-(2,5-dioxopyrrolidin-3-yl)phenoxy]butoxy]phenyl]pyrrolidine-2,5-dione Structure

3-[4-[4-[4-(2,5...

2,2'-((butane-1,4-diylbis(oxy))bis(4,1-phenylene))disuccinic acid Structure

2,2'-((butane-1...

~%

3-[4-[4-[4-(2,5-dioxopyrrolidin-3-yl)phenoxy]butoxy]phenyl]pyrrolidine-2,5-dione Structure

3-[4-[4-[4-(2,5...

tetraethyl 2,2'-(((butane-1,4-diylbis(oxy))bis(4,1-phenylene))bis(methanylylidene))dimalonate Structure

tetraethyl 2,2'...

~%

3-[4-[4-[4-(2,5-dioxopyrrolidin-3-yl)phenoxy]butoxy]phenyl]pyrrolidine-2,5-dione Structure

3-[4-[4-[4-(2,5...

4,4’-(1,5-Pentanediyl)dioxydibenzaldehyde Structure

4,4’-(1,5-Penta...

~%

3-[4-[5-[4-(2,5-dioxopyrrolidin-3-yl)phenoxy]pentoxy]phenyl]pyrrolidin e-2,5-dione Structure

3-[4-[5-[4-(2,5...

4-hydroxybenzaldehyde Structure

4-hydroxybenzal...

~%

3-[4-[5-[4-(2,5-dioxopyrrolidin-3-yl)phenoxy]pentoxy]phenyl]pyrrolidin e-2,5-dione Structure

3-[4-[5-[4-(2,5...

2,2'-((pentane-1,5-diylbis(oxy))bis(4,1-phenylene))disuccinic acid Structure

2,2'-((pentane-...

~%

3-[4-[5-[4-(2,5-dioxopyrrolidin-3-yl)phenoxy]pentoxy]phenyl]pyrrolidin e-2,5-dione Structure

3-[4-[5-[4-(2,5...

tetraethyl 2,2'-(((pentane-1,5-diylbis(oxy))bis(4,1-phenylene))bis(methanylylidene))dimalonate Structure

tetraethyl 2,2'...

~%

3-[4-[5-[4-(2,5-dioxopyrrolidin-3-yl)phenoxy]pentoxy]phenyl]pyrrolidin e-2,5-dione Structure

3-[4-[5-[4-(2,5...

4-hydroxybenzaldehyde Structure

4-hydroxybenzal...

1,3-Dichloropropane Structure

1,3-Dichloropropane

~%

1,3-Bis(4-formylphenoxy)propane Structure

1,3-Bis(4-formy...

4-(3-chloropropoxy)benzaldehyde Structure

4-(3-chloroprop...

4,4’-(1,6-Hexanediyl)dioxydibenzaldehyde Structure

4,4’-(1,6-Hexan...

~%

3-[4-[6-[4-(2,5-dioxopyrrolidin-3-yl)phenoxy]hexoxy]phenyl]pyrrolidine-2,5-dione Structure

3-[4-[6-[4-(2,5...

4-hydroxybenzaldehyde Structure

4-hydroxybenzal...

~%

3-[4-[6-[4-(2,5-dioxopyrrolidin-3-yl)phenoxy]hexoxy]phenyl]pyrrolidine-2,5-dione Structure

3-[4-[6-[4-(2,5...

2,2'-((hexane-1,6-diylbis(oxy))bis(4,1-phenylene))disuccinic acid Structure

2,2'-((hexane-1...

~%

3-[4-[6-[4-(2,5-dioxopyrrolidin-3-yl)phenoxy]hexoxy]phenyl]pyrrolidine-2,5-dione Structure

3-[4-[6-[4-(2,5...

tetraethyl 2,2'-(((hexane-1,6-diylbis(oxy))bis(4,1-phenylene))bis(methanylylidene))dimalonate Structure

tetraethyl 2,2'...

~%

3-[4-[6-[4-(2,5-dioxopyrrolidin-3-yl)phenoxy]hexoxy]phenyl]pyrrolidine-2,5-dione Structure

3-[4-[6-[4-(2,5...

1,7-Bis(4-formylphenoxy)heptane Structure

1,7-Bis(4-formy...

~%

3-[4-[7-[4-(2,5-dioxopyrrolidin-3-yl)phenoxy]heptoxy]phenyl]pyrrolidin e-2,5-dione Structure

3-[4-[7-[4-(2,5...

4-hydroxybenzaldehyde Structure

4-hydroxybenzal...

~%

3-[4-[7-[4-(2,5-dioxopyrrolidin-3-yl)phenoxy]heptoxy]phenyl]pyrrolidin e-2,5-dione Structure

3-[4-[7-[4-(2,5...

2,2'-((heptane-1,7-diylbis(oxy))bis(4,1-phenylene))disuccinic acid Structure

2,2'-((heptane-...

~%

3-[4-[7-[4-(2,5-dioxopyrrolidin-3-yl)phenoxy]heptoxy]phenyl]pyrrolidin e-2,5-dione Structure

3-[4-[7-[4-(2,5...

tetraethyl 2,2'-(((heptane-1,7-diylbis(oxy))bis(4,1-phenylene))bis(methanylylidene))dimalonate Structure

tetraethyl 2,2'...

~%

3-[4-[7-[4-(2,5-dioxopyrrolidin-3-yl)phenoxy]heptoxy]phenyl]pyrrolidin e-2,5-dione Structure

3-[4-[7-[4-(2,5...

4-hydroxybenzaldehyde Structure

4-hydroxybenzal...

~%

4,4’-(1,5-Pentanediyl)dioxydibenzaldehyde Structure

4,4’-(1,5-Penta...

4-hydroxybenzaldehyde Structure

4-hydroxybenzal...

1,3-Dichloropropane Structure

1,3-Dichloropropane

~%

1,3-Bis(4-formylphenoxy)propane Structure

1,3-Bis(4-formy...

4-(3-chloropropoxy)benzaldehyde Structure

4-(3-chloroprop...

4,4’-(1,8-Octanediyl)dioxydibenzaldehyde Structure

4,4’-(1,8-Octan...

~%

3-[4-[8-[4-(2,5-dioxopyrrolidin-3-yl)phenoxy]octoxy]phenyl]pyrrolidine-2,5-dione Structure

3-[4-[8-[4-(2,5...

4-hydroxybenzaldehyde Structure

4-hydroxybenzal...

~%

3-[4-[8-[4-(2,5-dioxopyrrolidin-3-yl)phenoxy]octoxy]phenyl]pyrrolidine-2,5-dione Structure

3-[4-[8-[4-(2,5...

2,2'-((octane-1,8-diylbis(oxy))bis(4,1-phenylene))disuccinic acid Structure

2,2'-((octane-1...

~%

3-[4-[8-[4-(2,5-dioxopyrrolidin-3-yl)phenoxy]octoxy]phenyl]pyrrolidine-2,5-dione Structure

3-[4-[8-[4-(2,5...

N/A Structure

~%

3-[4-[8-[4-(2,5-dioxopyrrolidin-3-yl)phenoxy]octoxy]phenyl]pyrrolidine-2,5-dione Structure

3-[4-[8-[4-(2,5...

4,4’-(1,9-Nonanediyl)dioxydibenzaldehyde Structure

4,4’-(1,9-Nonan...

~%

3-[4-[9-[4-(2,5-dioxopyrrolidin-3-yl)phenoxy]nonoxy]phenyl]pyrrolidine-2,5-dione Structure

3-[4-[9-[4-(2,5...

4-hydroxybenzaldehyde Structure

4-hydroxybenzal...

~%

3-[4-[9-[4-(2,5-dioxopyrrolidin-3-yl)phenoxy]nonoxy]phenyl]pyrrolidine-2,5-dione Structure

3-[4-[9-[4-(2,5...

2,2'-((nonane-1,9-diylbis(oxy))bis(4,1-phenylene))disuccinic acid Structure

2,2'-((nonane-1...

~%

3-[4-[9-[4-(2,5-dioxopyrrolidin-3-yl)phenoxy]nonoxy]phenyl]pyrrolidine-2,5-dione Structure

3-[4-[9-[4-(2,5...

tetraethyl 2,2'-(((nonane-1,9-diylbis(oxy))bis(4,1-phenylene))bis(methanylylidene))dimalonate Structure

tetraethyl 2,2'...

~%

3-[4-[9-[4-(2,5-dioxopyrrolidin-3-yl)phenoxy]nonoxy]phenyl]pyrrolidine-2,5-dione Structure

3-[4-[9-[4-(2,5...

4,4’-(1,10-Decanediyl )dioxydibenzaldehyde Structure

4,4’-(1,10-Deca...

~%

3-[4-[10-[4-(2,5-dioxopyrrolidin-3-yl)phenoxy]decoxy]phenyl]pyrrolidin e-2,5-dione Structure

3-[4-[10-[4-(2,...

4-hydroxybenzaldehyde Structure

4-hydroxybenzal...

~%

3-[4-[10-[4-(2,5-dioxopyrrolidin-3-yl)phenoxy]decoxy]phenyl]pyrrolidin e-2,5-dione Structure

3-[4-[10-[4-(2,...

2,2'-((decane-1,10-diylbis(oxy))bis(4,1-phenylene))disuccinic acid Structure

2,2'-((decane-1...

~%

3-[4-[10-[4-(2,5-dioxopyrrolidin-3-yl)phenoxy]decoxy]phenyl]pyrrolidin e-2,5-dione Structure

3-[4-[10-[4-(2,...

tetraethyl 2,2'-(((decane-1,10-diylbis(oxy))bis(4,1-phenylene))bis(methanylylidene))dimalonate Structure

tetraethyl 2,2'...

~%

3-[4-[10-[4-(2,5-dioxopyrrolidin-3-yl)phenoxy]decoxy]phenyl]pyrrolidin e-2,5-dione Structure

3-[4-[10-[4-(2,...

1,4-Dibromobutane Structure

1,4-Dibromobutane

4-hydroxybenzaldehyde Structure

4-hydroxybenzal...

~%

4,4'-(1,4-Butanediyl)dioxydibenzaldehyde Structure

4,4'-(1,4-Butan...

4-(4-bromobutoxy)benzaldehyde Structure

4-(4-bromobutox...

4-hydroxybenzaldehyde Structure

4-hydroxybenzal...

~%

4,4’-(1,6-Hexanediyl)dioxydibenzaldehyde Structure

4,4’-(1,6-Hexan...

1,4-Dibromobutane Structure

1,4-Dibromobutane

4-hydroxybenzaldehyde Structure

4-hydroxybenzal...

~%

4,4'-(1,4-Butanediyl)dioxydibenzaldehyde Structure

4,4'-(1,4-Butan...

4-(4-bromobutoxy)benzaldehyde Structure

4-(4-bromobutox...

4-hydroxybenzaldehyde Structure

4-hydroxybenzal...

~%

4,4’-(1,10-Decanediyl )dioxydibenzaldehyde Structure

4,4’-(1,10-Deca...

4-hydroxybenzaldehyde Structure

4-hydroxybenzal...

~%

4,4’-(1,9-Nonanediyl)dioxydibenzaldehyde Structure

4,4’-(1,9-Nonan...

4-hydroxybenzaldehyde Structure

4-hydroxybenzal...

~%

4,4’-(1,8-Octanediyl)dioxydibenzaldehyde Structure

4,4’-(1,8-Octan...

1,3-Bis(4-formylphenoxy)propane Structure

1,3-Bis(4-formy...

~%

2-[4-[3-[4-(1,2-dicarboxyethyl)phenoxy]propoxy]phenyl]butanedioic acid Structure

2-[4-[3-[4-(1,2...

4-hydroxybenzaldehyde Structure

4-hydroxybenzal...

~%

2-[4-[3-[4-(1,2-dicarboxyethyl)phenoxy]propoxy]phenyl]butanedioic acid Structure

2-[4-[3-[4-(1,2...

Sodium cyanide Structure

tetraethyl 2,2'-(((propane-1,3-diylbis(oxy))bis(4,1-phenylene))bis(methanylylidene))dimalonate Structure

tetraethyl 2,2'...

~%

2-[4-[3-[4-(1,2-dicarboxyethyl)phenoxy]propoxy]phenyl]butanedioic acid Structure

2-[4-[3-[4-(1,2...

4,4'-[methylenebis(oxy)]bis benzaldehyde Structure

4,4'-[methylene...

~%

3-[4-[[4-(2,5-dioxopyrrolidin-3-yl)phenoxy]methoxy]phenyl]pyrrolidine-2,5-dione Structure

3-[4-[[4-(2,5-d...

4-hydroxybenzaldehyde Structure

4-hydroxybenzal...

~%

3-[4-[[4-(2,5-dioxopyrrolidin-3-yl)phenoxy]methoxy]phenyl]pyrrolidine-2,5-dione Structure

3-[4-[[4-(2,5-d...

tetraethyl 2,2'-(((methylenebis(oxy))bis(4,1-phenylene))bis(methanylylidene))dimalonate Structure

tetraethyl 2,2'...

~%

3-[4-[[4-(2,5-dioxopyrrolidin-3-yl)phenoxy]methoxy]phenyl]pyrrolidine-2,5-dione Structure

3-[4-[[4-(2,5-d...

2,2'-((methylenebis(oxy))bis(4,1-phenylene))disuccinic acid Structure

2,2'-((methylen...

~%

3-[4-[[4-(2,5-dioxopyrrolidin-3-yl)phenoxy]methoxy]phenyl]pyrrolidine-2,5-dione Structure

3-[4-[[4-(2,5-d...

1,2-DIPHENOXYETHANE Structure

1,2-DIPHENOXYETHANE

~%

3-[4-[2-[4-(2,5-dioxopyrrolidin-3-yl)phenoxy]ethoxy]phenyl]pyrrolidine-2,5-dione Structure

3-[4-[2-[4-(2,5...

4,4’-Ethanediyldioxydibenzaldhyde Structure

4,4’-Ethanediyl...

~%

3-[4-[2-[4-(2,5-dioxopyrrolidin-3-yl)phenoxy]ethoxy]phenyl]pyrrolidine-2,5-dione Structure

3-[4-[2-[4-(2,5...

4-hydroxybenzaldehyde Structure

4-hydroxybenzal...

~%

3-[4-[2-[4-(2,5-dioxopyrrolidin-3-yl)phenoxy]ethoxy]phenyl]pyrrolidine-2,5-dione Structure

3-[4-[2-[4-(2,5...

2,2'-((ethane-1,2-diylbis(oxy))bis(4,1-phenylene))disuccinic acid Structure

2,2'-((ethane-1...

~%

3-[4-[2-[4-(2,5-dioxopyrrolidin-3-yl)phenoxy]ethoxy]phenyl]pyrrolidine-2,5-dione Structure

3-[4-[2-[4-(2,5...

tetraethyl 2,2'-(((ethane-1,2-diylbis(oxy))bis(4,1-phenylene))bis(methanylylidene))dimalonate Structure

tetraethyl 2,2'...

~%

3-[4-[2-[4-(2,5-dioxopyrrolidin-3-yl)phenoxy]ethoxy]phenyl]pyrrolidine-2,5-dione Structure

3-[4-[2-[4-(2,5...

1,2-DIPHENOXYETHANE Structure

1,2-DIPHENOXYETHANE

N,N-Dimethylformamide Structure

N,N-Dimethylfor...

~29%

4,4’-Ethanediyldioxydibenzaldhyde Structure

4,4’-Ethanediyl...