New hydroxystilbenoid derivatives endowed with neuroprotective activity and devoid of interference with estrogen and aryl hydrocarbon receptor-mediated …

…, CG Screttas, ES Katsanou, M Micha-Screttas…

Index: Villalonga-Barber, Carolina; Meligova, Aggeliki K.; Alexi, Xanthippi; Steele, Barry R.; Kouzinos, Constantinos E.; Screttas, Constantinos G.; Katsanou, Efrosini S.; Micha-Screttas, Maria; Alexis, Michael N. Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 1 p. 339 - 351

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Citation Number: 8

Abstract

We have synthesized a series of new (E) stilbenoid derivatives containing hydroxy groups at ring positions identical or similar to those of trans-resveratrol and bearing one or two bulky electron donating groups ortho to 4′-OH and we have evaluated their neuroprotective activity using glutamate-challenged HT22 hippocampal neurons to model oxidative stress- induced neuronal cell death. The most active derivatives, 5-{(E)-2-[3, 5-bis (1-ethylpropyl)- ...