Synlett

Aryl alkyl ketones in a one-pot Gewald synthesis of 2-aminothiophenes

…, OY Rogozhnikova, TV Mikhalina, TI Troitskaya…

Index: Tormyshev, Victor M.; Trukhin, Dmitry V.; Rogozhnikova, Olga Yu.; Mikhalina, Tatiana V.; Troitskaya, Tatiana I.; Flinn, Anthony Synlett, 2006 , # 16 p. 2559 - 2564

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Citation Number: 29

Abstract

Abstract 2-Aminothiophene-3-carboxylates bearing various aryl groups at the 4-position are readily obtained in good to moderate yields by the one-pot Gewald reaction of aryl alkyl ketones with ethyl cyanoacetate and elemental sulfur in the presence of morpholinium acetate and excess morpholine.