Research on Chemical Intermediates

Synthesis and antimicrobial of some new substituted tetrazolomethylbenzo [d]-[1, 2, 3] triazole derivatives using 1H-benzo [d][1, 2, 3] triazole as starting material

OM Ali, AEGE Amr, EE Mostafa

Index: Ali, Omar M.; Amr, Abd El-Galil E.; Mostafa, Elsayed E. Research on Chemical Intermediates, 2014 ,  vol. 40,  # 4  p. 1545 - 1556

Full Text: HTML

Citation Number: 6

Abstract

Abstract A series of tetrazolomethylbenzo [d][1, 2, 3] triazole derivatives (2–14) have been synthesized and evaluated as antimicrobial agents from 1H-benzo [d][1, 2, 3] triazole (1) as starting material. The reaction of benzotriazole 1 with chloroacetonitrile afforded 2-(1 H- benzo [d][1, 2, 3]-triazol-1-yl) acetonitrile 2, which was reacted with sodium azide to give tetrazole derivative 3. Esterification of benzotriazole 1 with ethyl bromoacetate in the ...