Discovery of new small molecules that influence neuroblast cell migration from the subventricular zone

A Rolland, I Boquet, JC Norreel, V Moret…

Index: Rolland, Amandine; Boquet, Isabelle; Norreel, Jean-Chretien; Moret, Vincent; Laras, Younes; Kraus, Jean-Louis Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 1 p. 169 - 174

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Abstract

Using SVZ (subventricular zone) tissue explants from one-day-old mice, we investigated the activity of new amino aromatic disulfide analogues and polyazamacrocycles on the migration of SVZ cells (neuroblasts). We found that among the tested analogues, non- peptidic disulfide derivative 8 significantly decreases the migration of neuroblasts from SVZ cells, and antagonized the stimulating activity of disulfide cyclic peptide 1. Discovery of ...

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