Synthesis and evaluation of hexahydropyrimidines and diamines as novel hepatitis C virus inhibitors

…, JM Heo, JS Lee, Y Ko, I Choi, J Cechetto, J Kim…

Index: Hwang, Jong Yeon; Kim, Hee-Young; Jo, Suyeon; Park, Eunjung; Choi, Jihyun; Kong, Sunju; Park, Dong-Sik; Heo, Ja Myung; Lee, Jong Seok; Ko, Yoonae; Choi, Inhee; Cechetto, Jonathan; Kim, Jaeseung; Lee, Jinhwa; No, Zaesung; Windisch, Marc Peter European Journal of Medicinal Chemistry, 2013 , vol. 70, p. 315 - 325

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Citation Number: 9

Abstract

Abstract In order to identify novel anti-hepatitis C virus (HCV) agents we devised cell-based strategies and screened phenotypically small molecule chemical libraries with infectious HCV particles, and identified a hit compound (1) containing a hexahydropyrimidine (HHP) core. During our cell-based SAR study, we observed a conversion of HHP 1 into a linear diamine (6), which is the active component in inhibiting HCV and exhibited comparable ...