Antitumor amino-substituted pyrido [3', 4': 4, 5] pyrrolo [2, 3-g] isoquinolines and pyrido [4, 3-b] carbazole derivatives: synthesis and evaluation of compounds resulting …

C Rivalle, F Wendling, P Tambourin…

Index: Rivalle, Christian; Wendling, Francoise; Tambourin, Pierre; Lhoste, Jean-Marc; Bisagni, Emile; Chermann, Jean-Claude Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 181 - 185

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Citation Number: 37

Abstract

New modifications of lo-[[3-(diethylamino) propyl] amino]-6-methyl-5H-pyrido [3', 4': 4, 5] pyrrolo [2, 3-g] isoquinoline (lb) and 1-[[3-(diethylamino) propyl] amino]-9-methoxy-5, 1l- dimethyl-6H-pyrido [4, 3-b] carbazole (4b), which display important antitumor properties, were performed either on the side chain or on the intercalating heterocycle. Side chains were introduced by direct substitution of the corresponding chloro derivatives and 6-N- ...