e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Tetrahedron letters
A convenient 'catch and release'synthesis of fused 2-alkylthio-pyrimidinones mediated by polymer-bound BEMP
GL Adams, TL Graybill, RM Sanchez, VW Magaard…
Index: Adams, Gregory L.; Graybill, Todd L.; Sanchez, Robert M.; Magaard, Victoria W.; Burton, George; Rivero, Ralph A. Tetrahedron Letters, 2003 , vol. 44, # 27 p. 5041 - 5045
A robust 'catch and release'synthesis of fused 2-alkylthio-3-substituted-pyrimidinones mediated by the polymer-bound base P-BEMP is described. This reengineered synthesis combines the efficiency of the classical synthesis (three steps, three diversity points) with the practical benefits of resin-bound reagents. The solution-phase strategy, reagent compatibility, and the results of a representative 48-member combinatorial library are ...
