Synlett

Synthesis of N, N-Dimethylpropanediamide and its Utility for the Preparation of 2-(Acetamidomethyl)-4-aryloxazoles

JA Ragan, M Burmaster, PD Hill

Index: Ragan, John A.; Burmaster, Michael; Hill, Paul D. Synlett, 2004 , # 8 p. 1334 - 1338

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Citation Number: 3

Abstract

Oxazoles are an important class of heterocycles, due to their ubiquity as both secondary metabolites and pharmacologically active agents. [1] We recently required a method for preparing 2-(acetamidomethyl)-4-aryl-oxazoles such as 2 (Figure [1] ). Preparation of 2-alkyl-substituted oxazoles from primary amides and α-bromoketones is known, [2] suggesting that direct access to oxazole 2 could be realized from bis-amide 1 and the appropriate bromoketone. While ...