Palladium??Catalyzed Tandem Alkenyl and Aryl C N Bond Formation: A Cascade N??Annulation Route to 1??Functionalized Indoles

MC Willis, GN Brace, IP Holmes

Index: Willis, Michael C.; Brace, Gareth N.; Holmes, Ian P. Angewandte Chemie - International Edition, 2005 , vol. 44, # 3 p. 403 - 406

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Citation Number: 178

Abstract

Indoles are preeminent amongst the heterocyclic motifs found in both designed medicinal agents and in natural products, and accordingly there exists a large and varied selection of methods for their preparation.[1] The majority of syntheses incorporate the key nitrogen atom of the indole nucleus early in the synthetic route. This can be problematic if systematic variation of the N-substituent is required without recourse to functionalization of the ...