Regioselective and Stereospecific Cross??Coupling of Primary Allylic Amines with Boronic Acids and Boronates through Palladium??Catalyzed C N Bond Cleavage

MB Li, Y Wang, SK Tian

Index: Li, Man-Bo; Wang, Yong; Tian, Shi-Kai Angewandte Chemie - International Edition, 2012 , vol. 51, # 12 p. 2968 - 2971

Full Text: HTML

Citation Number: 64

Abstract

The cross-coupling of allylic electrophiles with boronic acids and boronates is extremely useful for the formation of CÀC bonds and for the introduction of the allyl moieties to target compounds.[1, 2] Allylic halides,[3] esters,[4] carbonates,[4f, g, 5] phosphates,[6] and alcohols [7] have been identified as allylic electrophiles with significantly different reactivity and selectivity. It is noteworthy that the employment of an allylic alcohol as the allylic ...