Synthesis

Design, synthesis and structure-odor correlation of novel spiro [4.5]-decan-2-ones

P Kraft, R Cadalbert

Index: Kraft, Philip; Cadalbert, Riccardo Synthesis, 2002 , # 15 p. 2243 - 2253

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Citation Number: 6

Abstract

Abstract Dehydration and Rupe rearrangement of 2-(3, 3-dimethylcyclohexyl) hex-3-yne-2, 5- diol (9) furnished as a 3% byproduct the intense vetiver-like smelling 4, 7, 7-trimethyl-1- methylenespiro [4.5] decan-2-one (11). Motivated by the commercial importance of vetiver oil and the lack of synthetic substitutes as well as the lack of insight into the structural requirements for vetiver odorants, an efficient synthetic route to vetiver-like smelling ...