Probing active cocaine vaccination performance through catalytic and noncatalytic hapten design

…, T Whitfield, MS Hixon, Y Grant, GF Koob…

Index: Cai, Xiaoqing; Whitfield, Timothy; Hixon, Mark S.; Grant, Yanabel; Koob, George F.; Janda, Kim D. Journal of Medicinal Chemistry, 2013 , vol. 56, # 9 p. 3701 - 3709

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Citation Number: 17

Abstract

Presently, there are no FDA-approved medications to treat cocaine addiction. Active vaccination has emerged as one approach to intervene through the rapid sequestering of the circulating drug, thus terminating both psychoactive effects and drug toxicity. Herein, we report our efforts examining two complementary, but mechanistically distinct active vaccines, ie, noncatalytic and catalytic, for cocaine treatment. A cocaine-like hapten GNE and a ...