The sulphonamide derivatives are synthesized by two component condensation of alkyl bromide and sodium arylsulphonamide using N-methyl-2-pyrrolidone (NMP) as a reaction medium. This method results in high yields without the formation of unwanted side products, and expanding substrate scopes.
![4-methyl-N-[[4-[[(4-methylphenyl)sulfonylamino]methyl]phenyl]methyl]benzenesulfonamide Structure](https://image.chemsrc.com/caspic/225/5011-10-9.png)
