Stereospecific hydrogen-bonding in mononucleotide adducts of platinum anticancer complexes in aqueous solution

SJ Berners-Price, U Frey, JD Ranford…

Index: Berners-Price, Susan J.; Frey, Urban; Ranford, John D.; Sadler, Peter J. Journal of the American Chemical Society, 1993 , vol. 115, # 19 p. 8649 - 8659

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Citation Number: 78

Abstract

Abstract: The ammine and amine NH'H NMR resonances of Pt (I1) complexes containing 5'- phosphate derivatives of nucleobases undergo significant low-field shifts in aqueous solution consistent with stereospecific H-bonding between Pt-NH protons and cis nucleotide 5'-phosphate groups. The effects are strongest for NH protons held rigidly in a chelate ring (ethylenediamine, en, complexes), when the phosphate is fully deprotonated, and when ...