Tetrahedron

An expedient route to highly functionalized 2H-chromene-2-thiones via ring annulation of β-oxodithioesters catalyzed by InCl 3 under solvent-free conditions

RK Verma, GK Verma, K Raghuvanshi, MS Singh

Index: Verma, Rajiv Kumar; Verma, Girijesh K.; Raghuvanshi, Keshav; Singh, Maya Shankar Tetrahedron, 2011 , vol. 67, # 3 p. 584 - 589

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Citation Number: 38

Abstract

A convenient and one-pot synthesis of 3-aroyl/heteroaroyl-2H-chromene-2-thiones and benzo [f] 2H-chromene-2-thiones has been developed by the condensation of β- oxodithioesters and salicylaldehydes/α-hydroxynaphthaldehydes in the presence of indium trichloride under solvent-free conditions. The reaction is operationally facile, readily scalable, and offers rapid entry into differentially substituted chromene-2-thione scaffolds.