Pancreatic beta-cells are responsible for the production and release of insulin, a hormone that controls the level of glucose in the blood. Beta-cell mass is markedly reduced in both insulin-dependent and non-insulin-dependent diabetes mellitus.[1–5] The noninvasive estimation of beta-cell mass by imaging would have a significant impact on the management of clinical diabetes, pancreas-and/or isletcell transplantation, and the understanding of the ...