Tetrahedron

Synthetic studies on Ecteinascidin-743: synthesis of building blocks through Sharpless asymmetric dihydroxylation and aza-Michael reactions

S Chandrasekhar, NR Reddy, YS Rao

Index: Chandrasekhar; Reddy, N. Ramakrishna; Rao, Y. Srinivasa Tetrahedron, 2006 , vol. 62, # 51 p. 12098 - 12107

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Citation Number: 44

Abstract

A practical and an efficient synthesis of three building blocks of tetrahydroisoquinoline alkaloid Ecteinascidin-743 was accomplished, starting from readily available piperonal, 2- methyl anisole, and veratraldehyde. A combination of Vilsmeier–Haack reaction and Sharpless asymmetric dihydroxylation was employed for the synthesis of building blocks A and B whereas a Heck reaction in PEG-2000 and aza-Michael reactions were employed ...