Tetrahedron Letters

Development of one-pot synthesis of α-hydroxy α-trifluoromethyl amides

Z Meng, WE Butcher

Index: Meng, Zhaoyang; Butcher, William E. Tetrahedron Letters, 2013 , vol. 54, # 37 p. 5133 - 5136

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Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... An efficient one-pot-three-step method has been developed to assemble readily available aryl or heteroaryl halides, methyl trifluoropyruvate, and amines into biologically important α-hydroxy α-trifluoromethyl amides without isolation of any intermediates. ... Examples of biologically active ...