e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Tetrahedron
Unusual Friedel-Crafts reactions, IX. One-step ortho-acylation of phenols with α, β-unsaturated acyl chlorides. Synthesis of 2'-hydroxychalcones and sorbicillin …
F Bigi, G Casiraghi, G Casnati, S Marchesi, G Sartori…
The reaction of bromomagnesium phenolates 1 in toluene with α, β-unsaturated acyl chlorides 2 at room temperature provides a straightforward highly selective synthesis of α, β- unsaturated 2-hydroxyarylketones 3. 2'-Hydroxychalcones, ortho-sorbylphenols including sorbicillin 3g, and ortho-propiolylphenols were usefully synthesized by this way. This reaction provides a further example of the synthetic versatility of the chelation-controlled ...
