Synthesis and pharmacological study of antiarrhythmic activity of quaternary derivatives of trimecaine

…, AP Stankevichyus, VS Tseplene, AA Lubas

Index: Zhukauskaite, L. N.; Tsybusov, A. P.; Gendenshtein, E. I.; Stankevichyus, A. P.; Tseplene, V. S.; Lubas, A. A. Pharmaceutical Chemistry Journal, 1981 , vol. 15, # 6 p. 391 - 396 Khimiko-Farmatsevticheskii Zhurnal, 1981 , vol. 15, # 6 p. 43 - 48

Full Text: HTML

Citation Number: 0

Abstract

Opinions on the antiarrhythmic activity of the quaternary derivatives of aminoacetanilides are contradictory. It is assumed [12] that the transformation of~ into N~-leads to weakening or disappearance of the antiarrhythmic activity. However, according to later communications [13-~ 7], in experiment the quaternary derivatives of aminoacetaniiides exceeded lidocaine in both the strength and duration of the antiarrhythmic effect, and also in the absence of ...