Spectroscopic evidence for a spirooxirane intermediate in the synthesis of 4-(hydroxymethyl)-2-[(dimethylamino) methyl] thiazole

RA Johnson, KP Moder, TL Ward

Index: Johnson, Ross A.; Moder, Kenneth P.; Ward, Timothy L. Journal of Organic Chemistry, 1992 , vol. 57, # 10 p. 2869 - 2872

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Citation Number: 2

Abstract

The synthesis of 4-(hydroxymethyl) thiazole derivatives from the corresponding 4- (chloromethyl)-4-hydroxythiazole derivativea have been speculated to proceed through spirooxirane intermediatea NMR spectroscopy was used to provide evidence for the existence of such an intermediate in the synthesis of 4-(hydroxymethyl)-2-[(dimethylamino) methyllthiazole. Experimental conditions for the optimum formation and stabilization of a ...