e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Tetrahedron letters
N-(6-Methyl-2-pyridyl) acrylamide: a case of amide hydrolysis without the assistance of acid or base in the synthesis of water-driven H-bonded polymeric chains
K Ghosh, T Sen, R Fröhlich
Index: Ghosh, Kumaresh; Sen, Tanushree; Froehlich, Roland Tetrahedron Letters, 2007 , vol. 48, # 36 p. 6308 - 6311
Amide hydrolysis of N-(6-methyl-2-pyridyl) acrylamide without the assistance of either acid or base produces the aminopyridinium carboxylate salt at low or room temperature. The carboxylate ion and the free amine functionalities are cooperatively involved in hydrogen bonding with lattice water to form a new hydrogen-bonded polymeric chain.
