Antitumor activity of some polynitrile derivatives

…, AN Lyshchikov, YS Kayukov, VP Sheverdov

Index: Nasakin; Lyshchikov; Kayukov; Sheverdov Pharmaceutical Chemistry Journal, 2000 , vol. 34, # 4 p. 170 - 185

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Abstract

Investigation of the properties of organic polynitriles such as ethane-l,l,2,2-tetracarbonitrile and 4-oxoalkane- 1,1,2,2-tetracarbonitriles made it possible to develop an ap- proach to various classes of cyano-containing heterocyclic systems. Some of these compounds, possessing pesticide ac- tivity, were also found to be valuable products for further synthesis. For example, pyrroles with o-enaminonitrile frag- ments interact with formamide to form 4-amino-5-cyanopyr- ...