Asymmetric Hydrogenation of α??Primary and Secondary Amino Ketones: Efficient Asymmetric Syntheses of (−)??Arbutamine and (−)??Denopamine

G Shang, D Liu, SE Allen, Q Yang…

Index: Shang, Gao; Liu, Duan; Allen, Scott E.; Yang, Qin; Zhang, Xumu Chemistry - A European Journal, 2007 , vol. 13, # 27 p. 7780 - 7784

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Citation Number: 33

Abstract

Abstract Two β-receptor agonists (−)-denopamine and (−)-arbutamine were prepared in good yields and enantioselectivities by asymmetric hydrogenation of unprotected amino ketones for the first time by using Rh catalysts bearing electron-donating phosphine ligands. A series of α-primary and secondary amino ketones were synthesized and hydrogenated to produce various 1, 2-amino alcohols in good yields and with good enantioselectivies. This ...