Synthesis and evaluation of the male antifertility properties of a series of N-unsubstituted sulfamates

…, L Kraft, RA Mallory, G Powell, B Wong

Index: Hirsch, Allen F.; Kasulanis, Charles; Kraft, Larry; Mallory, Robert A.; Powell, Gregory; Wong, Benny Journal of Medicinal Chemistry, 1981 , vol. 24, # 7 p. 901 - 903

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Citation Number: 2

Abstract

A series of six aliphatic and one carbocyclic N-unsubstituted sulfamates have been synthesized and evaluated as potential male antifertility agenta. Three of the aliphatic sulfamates, 1, a-ethanediyl sulfamate (I), 1, 3-propanediyl sulfamate (2), and 1, 4butanediyl sulfamate (3), when administered orally to male rata caused a decrease in the number of pregnant females and/or implantation coupled with increased embryonic and fetal ...