Tetrahedron Letters

Potential metabolites of carcinogenic aza aromatic hydrocarbons synthesis of K-region oxide, phenol and dihydrodiols of 7-methylbenz [c] acridine

LJ Boux, HTA Cheung, GM Holder, L Moldovan

Index: Boux, L. J.; Cheung, H. T. A.; Holder, G. M.; Moldovan, L. Tetrahedron Letters, 1980 , vol. 21, p. 2923 - 2926

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Citation Number: 9

Abstract

C, 8H, 5N02, mp 248-249O, was synthesised by oxidation of 7-methylbenz [clacridin with osmium tetroxide in pyridine-chloroform. t5 The two dihydrodiols are not identical, nor are the corresponding diacetates tcis-diacetate (3d), C22H, 9N04, mp 351-3530; trans- diacetate(3b), C22H, gN04, mp 253-255'1. The trans-dihydrodiol(3a) was likely formed on ring-opening of the inter---mediate 5, 6-epoxide(2a) bytrifluoroacetic acid, The solvolysis ...