Synthesis and antiinflammatory activity of 2, 2'-diaminobiphenyl derivatives

…, A Guerrato, R Milanino, E Passarella…

Index: Calcinari, Romano; Case, Nadia; Guerrato, Alfredo; Milanino, Roberto; Passarella, Elda; et al. Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 632 - 634

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Citation Number: 5

Abstract

(Method C, Compound 18). As previously described in method B, 6.5 g (0.05 mol) of p- hydroxyphenylacetonitrile, 2.5 mL of absolute ethanol, and 70 mL of anhydrous chloroform were mixed and treated with dry hydrogen chloride. After ether was removed, the residue was combined with 150 mL of acetic acid and 6.42 g (0.03 mol) of 2-amino-2'-nitrobiphenyl. 2 The mixture was heated at 90 “C for about 16 h and, after cooling to about 30 “C, the ...