European journal of medicinal chemistry

Synthesis and in vitro cytotoxic activity of pyrrolo [2, 3-e] indole derivatives and a dihydro benzoindole analogue

L Chacón-Garcı́a, R Martı́nez

Index: Chacon-Garcia, Luis; Martinez, Roberto European Journal of Medicinal Chemistry, 2002 , vol. 37, # 3 p. 261 - 266

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Citation Number: 24

Abstract

The synthesis of pyrrolo [2, 3-e] indole derivatives with the structural characteristics of DNA bis-and mono-intercalators are described. A dihydro benzoindol analogue was also synthesised to elucidate the major structural requirements for cytotoxic activity. A biological evaluation of the test compounds was carried out in six different tumoral cell lines. The factors that affect the cytotoxic activity appear to be the substituents on the phenyl group, ...