Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of …

…, PM Nguyen, M Sablad, N Rozenkrants…

Index: Bonnefous, Celine; Payne, Joseph E.; Roppe, Jeffrey; Zhuang, Hui; Chen, Xiaohong; Symons, Kent T.; Nguyen, Phan M.; Sablad, Marciano; Rozenkrants, Natasha; Zhang, Yan; Wang, Li; Severance, Daniel; Walsh, John P.; Yazdani, Nahid; Shiau, Andrew K.; Noble, Stewart A.; Rix, Peter; Rao, Tadimeti S.; Hassig, Christian A.; Smith, Nicholas D. Journal of Medicinal Chemistry, 2009 , vol. 52, # 9 p. 3047 - 3062

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Citation Number: 47

Abstract

There are three isoforms of dimeric nitric oxide synthases (NOS) that convert arginine to citrulline and nitric oxide. Inducible NOS is implicated in numerous inflammatory diseases and, more recently, in neuropathic pain states. The majority of existing NOS inhibitors are either based on the structure of arginine or are substrate competitive. We describe the identification from an ultra high-throughput screen of a novel series of quinolinone small ...