Tetrahedron letters

Three-step synthesis of 4-(2′-hydroxyethyl) azetidin-2-one and its substituted derivatives from 4-acetoxy-2-pyridones

C Kaneko, T Naito, A Saito

Index: Kaneko, Chikara; Naito, Toshihiko; Saito, Akemi Tetrahedron Letters, 1984 , vol. 25, # 15 p. 1591 - 1594

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Citation Number: 8

Abstract

Abstract 4-(2'-Hydroxyethyl) azetidin-2-one, an important synthetic intermediate for carbapenem, and its substituted derivatives have been synthesized from 4-acetoxy-2- pyridones by photolysis, catalytic hydrogenation, followed by basic hydrolysis in the presence of sodium borohydride.