A Stereodivergent Strategy for the Preparation of Corynantheine and Ipecac Alkaloids, Their Epimers, and Analogues: Efficient Total Synthesis of (−)?? …

…, J Bah, A Wohlfarth, J Franzen

Index: Zhang, Wei; Bah, Juho; Wohlfarth, Andreas; Franzen, Johan Chemistry - A European Journal, 2011 , vol. 17, # 49 p. 13814 - 13824

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Citation Number: 35

Abstract

Abstract Here we present a general and common catalytic asymmetric strategy for the total and formal synthesis of a broad number of optically active natural products from the corynantheine and ipecac alkaloid families, for example, indolo [2, 3-a]-and benzo [a] quinolizidines. Construction of the core alkaloid skeletons with the correct absolute and relative stereochemistry relies on an enantioselective and diastereodivergent one-pot ...