Abstract: A convergent synthesis of the natural macrocycle (-)-maysine (3) has been accomplished involving only a single separation of epimers at C-10. The scheme involved the preparation of three major fragments:(a) the western zone, 4;(b) the southern zone, 6; and (c) the northeastern zone in enantiomerically pure from (+)-37. Each of these components was coupled through the appropriate functionality leading to the target ...
