Total synthesis of the latrunculins

…, SW Remiszewski, NJ Liverton, R Zibuck

Index: Smith III, Amos B.; Leahy, James W.; Noda, Ichio; Remiszewski, Stacy W.; Liverton, Nigel J.; Zibuck, Regina Journal of the American Chemical Society, 1992 , vol. 114, # 8 p. 2995 - 3007

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Citation Number: 59

Abstract

Abstract: The total syntheses of (+)-latrunculin A (1) and (+)-latrunculin B (2), two architecturally novel toxins isolated from the Red Sea sponge Latrunculia magnifica (Keller), have been achieved via highly convergent and stereocontrolled routes (longest linear sequences, 16 and 12 steps, respectively). Formal syntheses of scalemic latrunculins C (3) and M (5) also derive from the construction of 2. Central features of the unified synthetic ...