2-Thiazolidinone,4-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-,(4R)-
![2-Thiazolidinone,4-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-,(4R)- Structure](https://image.chemsrc.com/caspic/303/76343-94-7.png)
2-Thiazolidinone,4-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-,(4R)- structure
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Common Name | 2-Thiazolidinone,4-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-,(4R)- | ||
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| CAS Number | 76343-94-7 | Molecular Weight | 395.51300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H29NO5S | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of 2-Thiazolidinone,4-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-,(4R)-Latrunculin B, an antimicrobial marine alkaloid, is an actin polymerization inhibitor. Latrunculin B regulates pulmonary vein electrophysiological characteristics and attenuates stretch-induced arrhythmogenesis[1][2]. Antifungal and antiprotozoal activity. |
| Name | latrunculin B |
|---|---|
| Synonym | More Synonyms |
| Description | Latrunculin B, an antimicrobial marine alkaloid, is an actin polymerization inhibitor. Latrunculin B regulates pulmonary vein electrophysiological characteristics and attenuates stretch-induced arrhythmogenesis[1][2]. Antifungal and antiprotozoal activity. |
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| Related Catalog | |
| In Vitro | Latrunculin B displays growth inhibition of HeLa cells with an IC50 value of 1.4 μM[1]. Latrunculin B modulates electrophysiological characteristics and arrhythmogenesis in pulmonary vein cardiomyocytes. Latrunculin B (100 nM) decreases the spontaneous electrical activity by 16±4% in pulmonary vein (PV) preparations. Latrunculin B (100 nM) decreases the late Na+ current, L-type Ca2+ current, Na+/Ca2+ exchanger current, and stretch-activated BKCa current in PV cardiomyocytes. Latrunculin B reduces the transient outward K+ current and ultra-rapid delayed rectifier K+ current, but increases the delayed rectifier K+ current in isolated PV cardiomyocytes. Latrunculin B (100 nM) decreases intracellular Ca2+ transient and sarcoplasmic reticulum Ca2+ content in PV cardiomyocytes. Latrunculin B attenuates stretch-induced increased spontaneous electrical activity and trigger activity[2]. |
| References |
| Molecular Formula | C20H29NO5S |
|---|---|
| Molecular Weight | 395.51300 |
| Exact Mass | 395.17700 |
| PSA | 110.16000 |
| LogP | 3.63220 |
| InChIKey | NSHPHXHGRHSMIK-PZDDVPKQSA-N |
| SMILES | CC1=CC(=O)OC2CC(CCC(C)C=CCC1)OC(O)(C1CSC(=O)N1)C2 |
| Storage condition | 20°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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Arabidopsis dynamin-related proteins, DRP2A and DRP2B, function coordinately in post-Golgi trafficking.
Biochem. Biophys. Res. Commun. 456(1) , 238-44, (2015) Dynamin-related proteins (DRPs) are large GTPases involved in a wide range of cellular membrane remodeling processes. In Arabidopsis thaliana, two paralogous land plant-specific type DRPs, DRP2A and D... |
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Morphological effects on expression of growth differentiation factor 15 (GDF15), a marker of metastasis.
J. Cell Physiol. 229(3) , 362-73, (2014) Cancer cells typically demonstrate altered morphology during the various stages of disease progression as well as metastasis. While much is known about how altered cell morphology in cancer is a resul... |
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The formation of cortical actin arrays in human trabecular meshwork cells in response to cytoskeletal disruption.
Exp. Cell Res. 328(1) , 164-71, (2014) The cytoskeleton of human trabecular meshwork (HTM) cells is known to be altered in glaucoma and has been hypothesized to reduce outflow facility through contracting the HTM tissue. Latrunculin B (Lat... |
| LATRUNCULIN B |
| LATRUNCULIN B,LATRUNCULIA MAGNIFICA |
| MFCD00270879 |
| LAT-B |
| LatrunculinBfromLutrunculiamagnifica |