Synthesis and biological evaluation of ureido and thioureido derivatives of 2-amino-2-deoxy-D-glucose and related aminoalcohols as N-acetyl-β-D-hexosaminidase …

C Tournaire-Arellano, S Younes-El Hage, P Valès…

Index: Tournaire-Arellano, Cecile; Younes-El Hage, Salome; Vales, Patricia; Caujolle, Raymond; Sanon, Albertine; Bories, Christian; Loiseau, Philippe M. Carbohydrate Research, 1998 , vol. 314, # 1-2 p. 47 - 63

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Citation Number: 9

Abstract

Ureido and thioureido derivatives of 2-acetamido-2-deoxy-β-d-glucose, 1-amino-1-deoxy-d- glucitol and 2-(2-aminoethoxy) ethanol were prepared as N-acetyl-β-d-hexosaminidase (NAHase) inhibitors and were evaluated on Trichomonasvaginalis NAHase. Although none showed complete inhibition of the enzyme at 100 μM, 1-amino-1-deoxy-d-glucitol derivatives acted as competitive inhibitors of the NAHase of T. vaginalis.