Synthesis and radiopharmacological study of insaturated derivatives of cysteamine

D Mesnard, L Miginiac, M Fatome, JD Laval…

Index: Mesnard; Miginiac; Fatome; et al. European Journal of Medicinal Chemistry, 1980 , vol. 15, # 3 p. 247 - 252

Full Text: HTML

Citation Number: 9

Abstract

Synthesis of many insaturated compounds derivated from cysteamine has been carried out in the three series: β-aminothioethers, β-aminothiols and thiazolidines. These products are more or less toxic, compared to corresponding saturated derivates. They generally have a higher radioprotective activity. The three most effective have a DRF equivalent to those of cysteamine, two of them having a lower toxicity

 Related Synthetic Route
3,3-dimethyl-pent-4-en-2-one Structure

4181-07-1

3,3-dimethyl-pe...

2-Aminoethanethiol Structure

60-23-1

2-Aminoethanethiol

~20%

2-(1,1-Dimethylallyl)-2-methylthiazolidine Structure

75606-47-2

2-(1,1-Dimethyl...

5,6-dimethylhept-5-en-2-one Structure

687-68-3

5,6-dimethylhep...

2-Aminoethanethiol Structure

60-23-1

2-Aminoethanethiol

~75%

Thiazolidine, 2-(3,4-dimethyl-3-pentenyl)-2-methyl- Structure

75606-60-9

Thiazolidine, 2...

Thiirane Structure

420-12-2

Thiirane

2-Phenylethanamine Structure

64-04-0

2-Phenylethanamine

~60%

Ethanethiol,2-[(2-phenylethyl)amino]- Structure

6197-28-0

Ethanethiol,2-[...

5-Hexen-2-one,5-methyl- Structure

3240-09-3

5-Hexen-2-one,5...

2-Aminoethanethiol Structure

60-23-1

2-Aminoethanethiol

~82%

2-methyl-2-(3-methylbut-3-enyl)-1,3-thiazolidine Structure

75606-51-8

2-methyl-2-(3-m...

2-Aminoethanethiol Structure

60-23-1

2-Aminoethanethiol

4-Pentenoic acid, 2-acetyl-, ethyl ester Structure

610-89-9

4-Pentenoic aci...

~50%

2-Thiazolidineacetic acid, 2-methyl-alpha-2-propenyl-, ethyl ester Structure

75606-53-0

2-Thiazolidinea...

6-Hepten-2-one (6CI,7CI,8CI,9CI) Structure

21889-88-3

6-Hepten-2-one ...

2-Aminoethanethiol Structure

60-23-1

2-Aminoethanethiol

~58%

2-Methyl-2-(4-pentenyl)thiazolidine Structure

75606-55-2

2-Methyl-2-(4-p...

5-Nonen-8-yn-2-one, (E)- (9CI) Structure

75606-72-3

5-Nonen-8-yn-2-...

2-Aminoethanethiol Structure

60-23-1

2-Aminoethanethiol

~70%

2-[(E)-hept-3-en-6-ynyl]-2-methyl-1,3-thiazolidine Structure

75606-69-8

2-[(E)-hept-3-e...

2-Heptanone Structure

110-43-0

2-Heptanone

2-Aminoethanethiol Structure

60-23-1

2-Aminoethanethiol

~78%

2-methyl-2-pentyl-1,3-thiazolidine Structure

875-15-0

2-methyl-2-pent...

Thiirane Structure

420-12-2

Thiirane

Propylamine Structure

107-10-8

Propylamine

~52%

2-(propylamino)ethanethiol Structure

5891-07-6

2-(propylamino)...

(E)-non-5-en-2-one Structure

75606-70-1

(E)-non-5-en-2-one

2-Aminoethanethiol Structure

60-23-1

2-Aminoethanethiol

~71%

trans-2-(3-Heptenyl)-2-methylthiazolidine Structure

75606-67-6

trans-2-(3-Hept...

bromoethyne Structure

593-61-3

bromoethyne

2-Aminoethanethiol Structure

60-23-1

2-Aminoethanethiol

~25%

2-prop-2-ynylsulfanylethanamine Structure

75606-28-9

2-prop-2-ynylsu...

Thiirane Structure

420-12-2

Thiirane

Hexylamine Structure

111-26-2

Hexylamine

~43%

2-(hexylamino)ethanethiol Structure

5891-04-3

2-(hexylamino)e...

Thiirane Structure

420-12-2

Thiirane

3-aminopropyne Structure

2450-71-7

3-aminopropyne

~62%

2-(prop-2-ynylamino)ethanethiol Structure

75606-30-3

2-(prop-2-ynyla...

Thiirane Structure

420-12-2

Thiirane

4-methoxybut-2-yn-1-amine Structure

75166-23-3

4-methoxybut-2-...

~45%

2-(4-methoxybut-2-ynylamino)ethanethiol Structure

75606-36-9

2-(4-methoxybut...

Thiirane Structure

420-12-2

Thiirane

N-(2-Propyn-1-yl)-2-propyn-1-amine Structure

6921-28-4

N-(2-Propyn-1-y...

~74%

2-(diprop-2-ynylamino)ethanethiol Structure

75606-37-0

2-(diprop-2-yny...

hexenal Structure

25166-87-4

hexenal

2-Aminoethanethiol Structure

60-23-1

2-Aminoethanethiol

~82%

trans-2-(3-Pentenyl)thiazolidine Structure

75606-39-2

trans-2-(3-Pent...

6-Heptyn-2-one (7CI,8CI,9CI) Structure

928-39-2

6-Heptyn-2-one ...

2-Aminoethanethiol Structure

60-23-1

2-Aminoethanethiol

~59%

2-Methyl-2-(4-pentenyl)thiazolidne Structure

75606-56-3

2-Methyl-2-(4-p...

Thiirane Structure

420-12-2

Thiirane

3-phenylpropanamine Structure

2038-57-5

3-phenylpropanamine

~50%

2-[(3-Phenylpropyl)amino]ethanethiol Structure

7081-80-3

2-[(3-Phenylpro...

Pent-4-ynal Structure

18498-59-4

Pent-4-ynal

2-Aminoethanethiol Structure

60-23-1

2-Aminoethanethiol

~65%

2-(3-Butynyl)thiazolidine Structure

75606-41-6

2-(3-Butynyl)th...

5-Heptyn-2-one (8CI,9CI) Structure

22592-18-3

5-Heptyn-2-one ...

2-Aminoethanethiol Structure

60-23-1

2-Aminoethanethiol

~76%

Thiazolidine, 2-methyl-2-(3-pentynyl)- Structure

75606-58-5

Thiazolidine, 2...

(E)-nona-5,8-dien-2-one Structure

75606-71-2

(E)-nona-5,8-di...

2-Aminoethanethiol Structure

60-23-1

2-Aminoethanethiol

~76%

2-[(3E)-hepta-3,6-dienyl]-2-methyl-thiazolidine Structure

75606-68-7

2-[(3E)-hepta-3...

Thiirane Structure

420-12-2

Thiirane

DI-BUT-2-YNYL-AMINE Structure

53146-06-8

DI-BUT-2-YNYL-AMINE

~73%

2-(Di(2-butynyl)amino)ethanethiol Structure

75606-38-1

2-(Di(2-butynyl...

Citronellal Structure

106-23-0

Citronellal

2-Aminoethanethiol Structure

60-23-1

2-Aminoethanethiol

~69%

2-(2,6-Dimethyl-5-heptenyl)thiazolidine Structure

75606-42-7

2-(2,6-Dimethyl...

5,6-Heptadien-2-one (8CI,9CI) Structure

20449-20-1

5,6-Heptadien-2...

2-Aminoethanethiol Structure

60-23-1

2-Aminoethanethiol

~73%

2-Methyl-2-(3,4-pentadienyl)thiazolidine Structure

75606-59-6

2-Methyl-2-(3,4...


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