ABSTRACT Asymmetric synthesis of hro-pyrrolo-isoquinoline and hro- indolizino-indole derivatives via a diastereoselective N-acyliminium ion cyclization of chiral enamides is described. The requisite chiral enamides were prepared from readily available L-malic acid. ... The isoquinoline and indole alkaloids are abundant in plant products' and ... N-acyliminium ion cyclization, although well known, have only recently been ... Spe~kamp,~ and others,436 such cyclizations ...
