Iridium-catalyzed regio-and enantioselective allylation of ketone enolates

T Graening, JF Hartwig

Index: Graening, Timm; Hartwig, John F. Journal of the American Chemical Society, 2005 , vol. 127, # 49 p. 17192 - 17193

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Citation Number: 122

Abstract

The regio-and enantioselective α-allylation of unstabilized ketone enolates with unsymmetrical allylic carbonates to form the branched substitution products in the presence of metallacyclic iridium catalysts is reported. The products, branched γ, δ-unsaturated ketones, were obtained from readily available silyl enol ethers and achiral Boc-protected allylic alcohols in high regioselectivities and enantioselectivities (91-96% ee). The ...

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