Tetrahedron Letters

Construction of a new type of chiral bidentate NHC ligands: copper-catalyzed asymmetric conjugate alkylation

T Uchida, T Katsuki

Index: Uchida, Tatsuya; Katsuki, Tsutomu Tetrahedron Letters, 2009 , vol. 50, # 33 p. 4741 - 4743

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Citation Number: 34

Abstract

We synthesized in three steps simple chiral bidentate NHC compounds that carry an achiral coordinating group as N-substituent and revealed that they serve as efficient chiral auxiliaries for the copper-catalyzed asymmetric conjugate addition of dialkylzinc to acyclic enones (up to 97% ee).