Chiral Brønsted Acid??Promoted Enantioselective Desymmetrization in an Intramolecular Schmidt Reaction of Symmetric Azido 1, 3??Hexanediones: Asymmetric …

M Yang, YM Zhao, SY Zhang, YQ Tu…

Index: Yang, Ming; Zhao, Yu-Ming; Zhang, Shu-Yu; Tu, Yong-Qiang; Zhang, Fu-Min Chemistry - An Asian Journal, 2011 , vol. 6, # 6 p. 1344 - 1347

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Abstract

Alkaloids containing azaquaternary pyrroloazepine skeletons including cephalotaxine [1] and stemonamine [2] are an important class of bioactive molecules in nature. How to directly and enantioselectively construct the azaquaternary pyrroloazepine skeleton remains a challenge. Desymmetrization reactions, which are used to synthesize chiral molecules, are proving to be a powerful method, and variations of this type of reaction have been well ...