A very straightforward route to 1-azabicyclo alkaloid scaffolds with several ring sizes is reported. The final bicyclic structures were built through a synthetic scheme that involved (i) the construction of dienic 4-piperidone systems by an imino-Diels-Alder reaction between aminotrienes and N-ω-vinylimines, in the presence of Yb (OTf) 3, and (ii) the ring-closing metathesis reaction of these cyclic dienes, under the influence of the first-generation ...
