An acyclic derivative of 3'-azido-3'-deoxythymidine,(R, S)-l-[l-(2-hydroxyethoxy)-3- azidopropyl] thymine (2), has been synthesized by a path involving Michael-type addition. Related thymidine analogues lacking the C (3')-C (4') bond were similarly obtained. The method provides a versatile new route to nucleoside analogues. The new compounds were found to be essentially inactive against human immunodeficiency virus type 1 (HIV-1) and ...
![1-[3-hydroxy-1-(2-hydroxyethoxy)propyl]-5-methylpyrimidine-2,4-dione Structure](https://image.chemsrc.com/caspic/082/117143-02-9.png)