The design of artificial allosteric systems is of great significance for regulating the catalytic activities and complexation properties of artificial receptors. 1 We have been interested in the exploitation of homotropic allosteric systems, which show the nonlinear amplification of binding events and chemical signals. 2 This phenomenon is useful to control the activities of an artificial receptor in an OFF–ON switching manner at a threshold condition. 1,2 Allosteric molecular ...